Phenotypes Associated with This Genotype

Genotype
MGI:3525190

• Allelic Composition: Tg(CAG-WRN*K577M)5025Wcl/0
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:95127 )

• hypersensitivity to 4-nitroquinoline-1-oxide

• reduced replicative potential

• reduced expression of the endogenous WRN protein

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Werner syndrome		DOID:5688	OMIM:277700	J:95127