Phenotypes Associated with This Genotype

Genotype
MGI:3526863

• Allelic Composition: Rsc1a1^tm1Koep/Rsc1a1^tm1Koep
• Genetic Background: B6.129-Rsc1a1^tm1Koep

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased fat cell size ( J:95148 )

• the mean abdominal fat cell volume was 40% larger than in wild-type

increased percent body fat/body weight ( J:95148 )

• fat content increased by 80% in 5 month old females

behavior/neurological

abnormal food intake ( J:95148 )

• showed a 15% higher cumulative food intake at 3 months of age but not at 5 months of age

digestive/alimentary system

increased intestinal glucose absorption ( J:95148 )

• small intestinal D-glucose uptake measured in jointly perfused small bowel and liver was increased 2-fold compared to wild-type

growth/size/body

abnormal body water content ( J:95148 )

• body water increased by 22% in 5 month old females

increased body size ( J:95148 )

• 5 month old mice were bigger than wild-type

increased body weight ( J:95148 )

• body weight of 3 month old mice, but not of newborns, was increased by 5% compared to wild-type

obese ( J:95148 )

• by 5 months of age, mice were obese, with a 30% increase in body weight

• in 5 month old females, total body mass was increased by 25%, dry body mass was increased by 22% and fat-free dried mass was increased by 22%

homeostasis/metabolism

increased circulating leptin level ( J:95148 )

• serum leptin concentration increased twofold in 5 month old mice but showed no difference from wild-type at 3 months of age

increased circulating cholesterol level ( J:95148 )

• serum cholesterol concentration was increased by 30% compared to wild-type

abnormal energy homeostasis ( J:95148 )

• increased energy balance (221 kJ) compared to wild-type (109 kJ), with homozygotes retaining 16.3% more energy, however no differences in energy consumption

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:95148