Analysis Tools
reproductive system
 |
• less decidual response to mechanical stimulation
• reduced response to estrogen treatment
|
 |
• growth reduced about 34% in castrated males after testosterone treatment
|
small testis
(
J:46528
)
|
|
• smaller testes but structurally normal
• 19% reduction in testis/body weight ratio
|
homeostasis/metabolism
|
• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit mild resistance to thyroid hormone compared with wild-type mice
|
endocrine/exocrine glands
|
|
• ductal development only about half normal at 8 weeks of age
• alveoli much less developed
|
|
|
• growth reduced about 34% in castrated males after testosterone treatment
|
small testis
(
J:46528
)
|
|
• smaller testes but structurally normal
• 19% reduction in testis/body weight ratio
|
behavior/neurological
|
• increased escape latency in a Morris water maze
• slower swim speed
|
|
• tended to fall in a hanging wire test about 29% earlier than controls
• shorter latency to falling in a rotarod test and less improvement with repeated testing
|
nervous system
|
• absent at birth
• gradually reached normal levels by about age 10 days
|
|
• development of Purkinje cell precursors delayed from E10.5 to around E12.5
|
embryo
|
|
• less decidual response to mechanical stimulation
• reduced response to estrogen treatment
|
integument
|
|
• ductal development only about half normal at 8 weeks of age
• alveoli much less developed
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| thyroid hormone resistance syndrome | DOID:11633 |
OMIM:188570 OMIM:274300 |
J:54182 | |
