Phenotypes Associated with This Genotype

Genotype
MGI:3528066

cx4

• Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr; Tg(HDexon1)62Gpb/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:95452 )

• mean lifespan of mutants was increased by 19.7% compared Tg(HDexon1)62Gpb transgenic mice

behavior/neurological

impaired coordination ( J:95452 )

• mutants showed a delayed onset of motor dysfunction compared to Tg(HDexon1)62Gpb transgenic mice at 9, 10, and 11 weeks of age

nervous system

abnormal striatum morphology ( J:95452 )

• 10 week-old mutants had 30-35% more huntingtin protein aggregates within the cerebral cortex and striatum than Tg(HDexon1)62Gpb transgenic mice

abnormal cerebral cortex morphology ( J:95452 )

• 10 week-old mutants had 30-35% more huntingtin protein aggregates within the cerebral cortex and striatum than Tg(HDexon1)62Gpb transgenic mice