Phenotypes Associated with This Genotype

Genotype
MGI:3528230

hm3

• Allelic Composition: Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr
• Genetic Background: involves: 129S1/SvImJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell adhesion ( J:95130 )

• fewer homozygous fibroblasts (20% versus 79% of wild-type) adhered to poly-L-coated or fibronectin coated slides

immune system

abnormal T cell physiology ( J:95130 )

• 24 hours after induction of apoptosis by dexamethasone treatment, homozygotes had smaller thymuses due to decreased viability of thymocytes and increased clearance of dead cells compared to controls, however mutants are viable, normal in size and weight, have normal separation of digits and open eyelids and no difference in thymocyte numbers, indicating that developmental apoptosis was not impaired

hematopoietic system

abnormal T cell physiology ( J:95130 )

• 24 hours after induction of apoptosis by dexamethasone treatment, homozygotes had smaller thymuses due to decreased viability of thymocytes and increased clearance of dead cells compared to controls, however mutants are viable, normal in size and weight, have normal separation of digits and open eyelids and no difference in thymocyte numbers, indicating that developmental apoptosis was not impaired