Phenotypes Associated with This Genotype

Genotype
MGI:3529778

cx44

• Allelic Composition: Cdkn1b^tm1Kin/Cdkn1b⁺; Lepr^db/Lepr^db
• Genetic Background: involves: C57BL/6J * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

polyphagia ( J:96047 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:96047 )

• islet mass, but not islet density, is significantly increased compared to Lepr single homozygotes

increased pancreatic beta cell number ( J:96047 )

• beta cell proliferation and the total number of beta cells are increased compared to Lepr single homozygotes; however the size of individual beta cells is similar to Lepr single homozygotes

growth/size/body

obese ( J:96047 )

homeostasis/metabolism

hyperglycemia ( J:96047 )

• developed more slowly and to a reduced extent compared to Lepr single homozygotes

increased circulating insulin level ( J:96047 )

hyperlipidemia ( J:96047 )

decreased body temperature ( J:96047 )