Phenotypes for Gzma Gzmb Prf1 MGI:3529809 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gzma^tm1Simn/Gzma^tm1Simn Gzmb^tm1Ley/Gzmb^tm1Ley Prf1^tm1Sdz/Prf1^tm1Sdz
Genetic Background	B6.Cg-Gzma^tm1Simn Gzmb^tm1Ley Prf1^tm1Sdz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gzma^tm1Simn mutation (8 available); any Gzma mutation (34 available)
Gzmb^tm1Ley mutation (7 available); any Gzmb mutation (29 available)
Prf1^tm1Sdz mutation (13 available); any Prf1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:90852 )

• WNV-infected triple homozygotes display prolonged mean survival time (MST) but significantly increased mortality (50%) relative to either wild-type (29%) or Prf1^tm1Sdz (18%) mice

immune system

immune system phenotype ( J:92718 )

N	• triple homozygotes develop a normal contact hypersensitivity (CHS) response (based on increase in ear thickness) to trinitrophenyl (TNP) relative to wild-type mice

increased susceptibility to parasitic infection ( J:81397 )

• decreased clearance and survival after infection with Trypanosoma cruzi

increased susceptibility to Flaviviridae infection ( J:90852 )

• triple homozygotes display increased susceptibility to West Nile flavivirus (WNV) infection relative to wild-type

• triple mutants show a higher level of infectious virus in brain relative to wild-type or Prf1^tm1Sdz mice at the same time point

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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