Phenotypes Associated with This Genotype

Genotype
MGI:3529938

• Allelic Composition: Vangl2^Lp/Vangl2^Lp
• Genetic Background: involves: CBA/Ca * LPT/Le

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neural plate morphology ( J:47700 )

• marked broadening and flattening of the neural plate ventral midline at E8.5

• fail to develop a sharp midline bending at E8.5

abnormal embryonic neuroepithelium morphology ( J:47700 )

open neural tube ( J:47700 )

• failure to initiate neural tube closure at the cervical/hindbrain boundry

• neural tube is open throughout the hindbrain and spinal region

craniorachischisis ( J:47700 )

embryo

embryo phenotype ( J:47700 )

N • more anterior neural fold development is more like controls

abnormal neural plate morphology ( J:47700 )

• marked broadening and flattening of the neural plate ventral midline at E8.5

• fail to develop a sharp midline bending at E8.5

abnormal embryonic neuroepithelium morphology ( J:47700 )

open neural tube ( J:47700 )

• failure to initiate neural tube closure at the cervical/hindbrain boundry

• neural tube is open throughout the hindbrain and spinal region

craniorachischisis ( J:47700 )

abnormal notochord morphology ( J:47700 )

• enlarged

• loosely organized

abnormal somite development ( J:47700 )

• poorly condensed

abnormal somite shape ( J:47700 )

• irregularly shaped

skeleton

abnormal sternum morphology ( J:47700 )

• sternal defects

rib fusion ( J:47700 )

• multiple rib fusions

abnormal vertebral arch development ( J:47700 )

• neural arches are unfused dorsally

• unfused arches are splayed apart

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:47700