Phenotypes Associated with This Genotype

Genotype
MGI:3530076

• Allelic Composition: Atrx^tm1Rjg/Y; Tg(Nes-cre)2472Pick/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:95953 )

♂ • reduced postnatal survival similar to Atrx hemizygotes that are heterozygous for Foxg1^tm1(cre)Skm

growth/size/body

decreased birth body size ( J:95953 )

♂ • mutants are smaller at birth

nervous system

loss of hippocampal neurons ( J:95953 )

♂ • not as severe as in Atrx hemizygotes that are heterozygous for Foxg1^tm1(cre)Skm

loss of cortex neurons ( J:95953 )

♂ • the frontal cortex is reduced in size especially in the caudal-medial cortex similar to Atrx hemizygotes that are heterozygous for Foxg1^tm1(cre)Skm but the severity of loss is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia-X-linked intellectual disability syndrome		DOID:0110030	OMIM:301040	J:95953