Phenotypes Associated with This Genotype

Genotype
MGI:3530366

• Allelic Composition: Gpc3^tm1Fil/Gpc3⁺
• Genetic Background: B6.Cg-Gpc3^tm1Fil

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cystic and dysplastic kidneys in Gpc3^tm1Fil/Gpc3⁺ mice

renal/urinary system

kidney cyst ( J:73877 )

♀ • from N4 on, some heterozygous females display cystic kidneys (also noted in a large proportion of mice from earlier backcrosses)

abnormal kidney development ( J:73877 )

♀ • from N4 on, some heterozygous females display dysplastic kidneys (also noted in a large proportion of mice from earlier backcrosses)

♀ • the degree of renal dysplasia varies from mouse to mouse

abnormal ureteric bud morphology ( J:73877 )

♀

impaired branching involved in ureteric bud morphogenesis ( J:73877 )

♀

growth/size/body

increased body weight ( J:73877 )

♀ • heterozygotes display an intermediate size between hemizygous mutant males and wild-type controls at all time points

kidney cyst ( J:73877 )

♀ • from N4 on, some heterozygous females display cystic kidneys (also noted in a large proportion of mice from earlier backcrosses)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Simpson-Golabi-Behmel syndrome type 1		DOID:0060248	OMIM:312870	J:73877