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Phenotypes Associated with This Genotype
Genotype
MGI:3531091
cx1
Allelic
Composition		 Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a19Cwe/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (37 available); any Prnp mutation (142 available)
Tg(Prnp)a19Cwe mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to prion infection ( J:32214 )
• scrapie-innoculated mice displayed typical scrapie symptoms, such as hind limb paresis, foot clasp reflex, kyphosis, ataxia, disorientation and minced gait
• incubation times to occurrence of first symptoms as well as the terminal state were shorter than wild-type control group

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory