Phenotypes Associated with This Genotype

Genotype
MGI:3531409

• Allelic Composition: Phox2a/Inppl1^tm1Ssch/Phox2a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:96443 )

• injection of insulin caused more profound hypoglycemia in heterozygotes than in wild-type mice

homeostasis/metabolism

improved glucose tolerance ( J:96443 )

• injection of D-glucose resulted in a more rapid glucose clearance in heterozygous compared to wild-type

abnormal glycogen homeostasis ( J:96443 )

• in response to insulin stimulation GLUT4 glucose transporter and glycogen synthesis are increased more profoundly in skeletal muscle of heterozygotes compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:96443