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Phenotypes Associated with This Genotype
Genotype
MGI:3573782
Allelic
Composition
Dmdtm1.1Khan/Y
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdtm1.1Khan mutation (0 available); any Dmd mutation (154 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• severe muscular hypertrophy and dystrophy were observed in the skeletal muscle and diaphragm
• degenerating muscle fibers with cellular infiltration and regenerated muscle appeared at 4 weeks of age
• extensive myofiber degeneration in diaphragm muscle at 4 weeks of age
• frequent muscle fiber necrosis peaking in 3-4 weeks old mice was observed

reproductive system
• hemizygous males were viable and normal in body size and external appearance, but they did not reproduced despite intensive mating

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Duchenne muscular dystrophy DOID:11723 OMIM:310200
J:96210


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory