Phenotypes Associated with This Genotype

Genotype
MGI:3573782

• Allelic Composition: Dmd^tm1.1Khan/Y
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

increased skeletal muscle fiber size ( J:96210 )

♂ • severe muscular hypertrophy and dystrophy were observed in the skeletal muscle and diaphragm

skeletal muscle fiber degeneration ( J:96210 )

♂ • degenerating muscle fibers with cellular infiltration and regenerated muscle appeared at 4 weeks of age

♂ • extensive myofiber degeneration in diaphragm muscle at 4 weeks of age

skeletal muscle fiber necrosis ( J:96210 )

♂ • frequent muscle fiber necrosis peaking in 3-4 weeks old mice was observed

reproductive system

male infertility ( J:96210 )

♂ • hemizygous males were viable and normal in body size and external appearance, but they did not reproduced despite intensive mating

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:96210