Phenotypes Associated with This Genotype

Genotype
MGI:3573788

• Allelic Composition: Nbn^tm1Nus/Nbn^tm2Nus; Tg(CD19-cre/ERT2)1Cgn/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell physiology ( J:96102 )

• recombined B lymphocytes show increased spontaneous DNA damage, chromosomal aberrations including tetraploidy, and Ig class-switch recombination is diminished

decreased B cell proliferation ( J:96102 )

• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G₂/M phase of the cell cycle, and relatively increased cell death is seen

decreased IgG level ( J:96102 )

• IgG, IgG1, IgG2b and IgG3 levels are reduced

• IgM levels are normal

decreased IgG1 level ( J:96102 )

decreased IgG2a level ( J:96102 )

decreased IgG2b level ( J:96102 )

decreased IgG3 level ( J:96102 )

hematopoietic system

abnormal B cell physiology ( J:96102 )

• recombined B lymphocytes show increased spontaneous DNA damage, chromosomal aberrations including tetraploidy, and Ig class-switch recombination is diminished

decreased B cell proliferation ( J:96102 )

• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G₂/M phase of the cell cycle, and relatively increased cell death is seen

decreased IgG level ( J:96102 )

• IgG, IgG1, IgG2b and IgG3 levels are reduced

• IgM levels are normal

decreased IgG1 level ( J:96102 )

decreased IgG2a level ( J:96102 )

decreased IgG2b level ( J:96102 )

decreased IgG3 level ( J:96102 )

cellular

decreased B cell proliferation ( J:96102 )

• after 72 hours in culture only 39% of mutant B cells had completed 3 or more cell divisions, cells accumulated in the G₂/M phase of the cell cycle, and relatively increased cell death is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nijmegen breakage syndrome		DOID:7400	OMIM:251260	J:96102