behavior/neurological
N |
• during tail suspension, a similar % (<20%) of wild-type and homozygous mutant mice tend to clasp
|
• at >40 weeks of age, homozygotes show an increase in the average distance between front and hind paws ('overlap' distance) relative to wild-type mice
|
• 1 out of 10 homozygotes (100 trials; 25-60 weeks of age) exhibit a convulsive spell consistent with a tonic-clonic seizure
|
growth/size/body
• at 34 weeks of age, some homozygotes exhibit an extreme size reduction relative to wild-type mice
|
homeostasis/metabolism
N |
• homozygotes display normal blood glucose levels relative to wild-type mice
|
nervous system
N |
• homozygotes display no extreme reductions in major brain regions or significant reactive gliosis relative to wild-type mice
|
• 1 out of 10 homozygotes (100 trials; 25-60 weeks of age) exhibit a convulsive spell consistent with a tonic-clonic seizure
|
• neuronal intranuclear inclusions (NIIs) are rarely observed in homozygotes up to 90 weeks of age; no NIIs are noted in wild-type brains
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Huntington's disease | DOID:12858 |
OMIM:143100 |
J:67074 |