Phenotypes Associated with This Genotype

Genotype
MGI:3574279

• Allelic Composition: Cecr2^{Gt(pGT1)1Hemc}/Cecr2^{Gt(pGT1)1Hemc}
• Genetic Background: FVB.129P2(C)-Cecr2^{Gt(pGT1)1Hemc}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:96325 )

N • exencephaly penetrance was 0% unlike in other genetic backgrounds

abnormal neural tube morphology ( J:177709 )

• increased cranial neural tube width

delayed neural tube closure ( J:177709 )

• at the 16 somite stage the neural tube is closed in only about half the embryos

exencephaly ( J:177709 )

• penetrance is 1.6% at greater than N10

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:177709 )

N • no cochlear defects are detected

embryo

abnormal neural tube morphology ( J:177709 )

• increased cranial neural tube width

delayed neural tube closure ( J:177709 )

• at the 16 somite stage the neural tube is closed in only about half the embryos

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	anencephaly	DOID:0060668	OMIM:206500	J:96325