Phenotypes Associated with This Genotype

Genotype
MGI:3574538

• Allelic Composition: Dok1^tm1Yyam/Dok1^tm1Yyam; Dok2^tm1Yyam/Dok2^tm1Yyam; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:95335 )

• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm

increased leukemia incidence ( J:95335 )

• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

enlarged lymph nodes ( J:95335 )

• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands

enlarged thymus ( J:95335 )

• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95335