Phenotypes Associated with This Genotype

Genotype
MGI:3574545

• Allelic Composition: Dok1^tm1Ppp/Dok1⁺; Tg(Tec-BCR/ABL1)5Hhi/0
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:95334 )

• loss of Dok1 shortened lifespan to about 307 days from about 325 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok1

neoplasm

increased leukemia incidence ( J:95334 )

• inactivation of Dok1 accelerated the onset of the chronic phase and the fatal blastic phase

• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:95334