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Phenotypes Associated with This Genotype
Genotype
MGI:3574546
Allelic
Composition
Dok2tm1Ppp/Dok2+
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• loss of Dok2 shortened lifespan to about 283 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2

neoplasm
• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase
• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:95334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory