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Phenotypes Associated with This Genotype
Genotype
MGI:3574636
Allelic
Composition
Tg(Msmb-TAg)183-2Xuan/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• moderately differentiated adenocarcinoma (prostate cancer) was detected by 16-19 weeks of age
• well-differentiated prostate cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 13% of transgenic mice and by 32 weeks or later, prostate cancer was detected in 40% of mice
• poorly differentiated prostate cancer started as early as 16 weeks of age and 8/10 poorly differentiated prostate cancers showed large visible tumors
• 2/3 of castrated mice showed visible, fair-sized carcinoma one month after castration, while 1/3 showed high grade prostatic intraepithelial neoplasia
• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks
• metastatic cells of prostatic origin were found in the lymph nodes with the lymph node cortex replaced with undifferentiated epithelial cells

endocrine/exocrine glands
• detected prostate hyperplasia by 10 weeks of age, with a few mice showing an unexpected appearance of hyperplasia at 16 to 32 weeks of age
• moderately differentiated adenocarcinoma (prostate cancer) was detected by 16-19 weeks of age
• well-differentiated prostate cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 13% of transgenic mice and by 32 weeks or later, prostate cancer was detected in 40% of mice
• poorly differentiated prostate cancer started as early as 16 weeks of age and 8/10 poorly differentiated prostate cancers showed large visible tumors
• 2/3 of castrated mice showed visible, fair-sized carcinoma one month after castration, while 1/3 showed high grade prostatic intraepithelial neoplasia
• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks

immune system
• transgenic mice with visible prostate tumors had enlarged renal lymph nodes

reproductive system
• detected prostate hyperplasia by 10 weeks of age, with a few mice showing an unexpected appearance of hyperplasia at 16 to 32 weeks of age
• moderately differentiated adenocarcinoma (prostate cancer) was detected by 16-19 weeks of age
• well-differentiated prostate cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 13% of transgenic mice and by 32 weeks or later, prostate cancer was detected in 40% of mice
• poorly differentiated prostate cancer started as early as 16 weeks of age and 8/10 poorly differentiated prostate cancers showed large visible tumors
• 2/3 of castrated mice showed visible, fair-sized carcinoma one month after castration, while 1/3 showed high grade prostatic intraepithelial neoplasia
• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory