Phenotypes Associated with This Genotype

Genotype
MGI:3574638

• Allelic Composition: Tg(Msmb-TAg)186-3Xuan/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:80313 )

• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks

increased carcinoma incidence ( J:80313 )

• by 24 weeks, some high grade prostatic intraepithelial neoplasia foci showed microinvasion of the stroma, however no distant metastasis was found

• well-differentiated pancreatic cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 40% of transgenic mice and by 32 weeks or later, pancreatic cancer was detected in 100% of mice

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:80313 )

♂ • detected prostate hyperplasia by 10 weeks of age

reproductive system

prostate gland epithelial hyperplasia ( J:80313 )

♂ • detected prostate hyperplasia by 10 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:80313