Phenotypes for Gnrhr MGI:3574973 MGI Mouse

reproductive system

arrest of male meiosis ( J:96941 )

• blocked at the midpachytene stages of meiosis

abnormal anogenital distance ( J:96941 )

• the anogenital distance is reduced

abnormal female reproductive system morphology ( J:96941 )

• the genital papilla is reduced in size

• overall the adult internal reproductive tract appears prepubescent

absent corpus luteum ( J:96941 )

absent tertiary ovarian follicles ( J:96941 )

• large antral follicles are absent

impaired ovarian folliculogenesis ( J:96941 )

• arrest at the early antral stage

uterus hypoplasia ( J:96941 )

• the uterus is thread-like and pale

abnormal male reproductive system morphology ( J:96941 )

• the genital papilla is reduced in size

• overall the adult internal reproductive tract appears prepubescent

small seminal vesicle ( J:96941 )

cryptorchism ( J:96941 )

small penis ( J:96941 )

small epididymis ( J:96941 )

• reduced in size

small gonad ( J:96941 )

small ovary ( J:96941 )

• ovaries are about 50% the size of normal littermates

decreased testis weight ( J:96941 )

• testes weigh 1/10 that of normal littermates

delayed vaginal opening ( J:96941 )

• opening of the vagina is delayed

homeostasis/metabolism

abnormal circulating hormone level ( J:96941 )

• decreased circulating levels of androstenedione

decreased circulating dihydrotestosterone level ( J:96941 )

decreased circulating testosterone level ( J:96941 )

decreased circulating progesterone level ( J:96941 )

decreased follicle stimulating hormone level ( J:96941 )

• the number of FSH positive cells is decreased in the pituitary

decreased circulating follicle stimulating hormone level ( J:96941 )

decreased luteinizing hormone level ( J:96941 )

• the number of LH positive cells is decreased in the pituitary

renal/urinary system