Phenotypes Associated with This Genotype

Genotype
MGI:3575312

• Allelic Composition: Nfe2l1^tm1Jefc/Nfe2l1^tm1Ywk; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:97188 )

• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice

increased liver adenoma incidence ( J:97188 )

• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice

homeostasis/metabolism

increased circulating alanine transaminase level ( J:97188 )

• at 4 weeks

immune system

liver inflammation ( J:97188 )

• infiltration of inflammatory cells are seen in 4 weeks old mutant mice liver

liver/biliary system

liver inflammation ( J:97188 )

• infiltration of inflammatory cells are seen in 4 weeks old mutant mice liver

hepatic necrosis ( J:97188 )

• note: apoptotic cells and necrosis are seen in 4 weeks old mutant mice liver

hepatic steatosis ( J:97188 )

• at 4 weeks, fatty vacuolated cells in liver had a 3-fold elevation in triglyceride levels

• lipid accumulation was also seen in cultures of primary hepatocytes derived from mutant mice

increased hepatocellular carcinoma incidence ( J:97188 )

• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice

increased liver adenoma incidence ( J:97188 )

• at 10-12 months, enlarged livers with multiple tumors were seen in 100% (12/12) mutant mice

liver fibrosis ( J:97188 )

• pericentral and pericellular fibrosis was seen in older animals

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:97188