Phenotypes Associated with This Genotype

Genotype
MGI:3575899

• Allelic Composition: Igh^tm1(Myc)Janz/Igh⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:160845 )

• tumors are more differentiated than tumors from Igh^tm1(Myc)Janz Tg(Emu-FGFR3)A5Wmk or Tg(Emu-FGFR3)D3Wmk heterozygotes

increased tumor incidence ( J:96785 , J:160845 )

• tumor incidence was 68% at 21 months of age (J:96785)

• 75% of mice developed tumors at a median age of 281 days unlike wild-type mice (J:160845)

increased B cell derived lymphoma incidence ( J:96785 , J:160845 )

• most prevalent tumors were lymphoblastic B cell lymphomas with a Burkitt-like 'starry sky' morphology due to tingible body macrophages (J:96785)

• 1/4 of lymphomas were diffuse large B cell lymphomas (J:96785)

• lymphoblastic B-cell lymphomas contain clonal cytogenetic aberrations (J:96785)

increased plasmacytoma incidence ( J:96785 , J:160845 )

• 1/5 of lymphomas were CD19⁺CD138⁺ plasmacytomas that exhibited varying degrees of differentiation, including plasmablastic, anaplastic, and plasmacytic variants (J:96785)

• 25% of tumor exhibit plasmacytoid differentiation (J:160845)

immune system

increased B cell apoptosis ( J:96785 )

• elevated apoptosis in B cells of 4- to 6-month old tumor-free mutants

increased B cell proliferation ( J:96785 )

• B cells proliferated, on average, 3.8 times faster than controls and showed a 3.5-fold increase in the number of cells in S phase of the cell cycle in 4- to 6-month old, tumor-free mutants

• B splenocytes proliferated more vigorously than controls after stimulation with LPS

enlarged spleen ( J:96785 )

• spleen was enlarged in 4- to 6-month old tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

enlarged lymph nodes ( J:96785 )

• lymph nodes were enlarged in 4- to 6-month tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

lymphoid hyperplasia ( J:96785 )

• observed in 4- to 6-month old tumor-free mutants

hematopoietic system

increased B cell apoptosis ( J:96785 )

• elevated apoptosis in B cells of 4- to 6-month old tumor-free mutants

increased B cell proliferation ( J:96785 )

• B cells proliferated, on average, 3.8 times faster than controls and showed a 3.5-fold increase in the number of cells in S phase of the cell cycle in 4- to 6-month old, tumor-free mutants

• B splenocytes proliferated more vigorously than controls after stimulation with LPS

enlarged spleen ( J:96785 )

• spleen was enlarged in 4- to 6-month old tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

cellular

increased B cell apoptosis ( J:96785 )

• elevated apoptosis in B cells of 4- to 6-month old tumor-free mutants

increased B cell proliferation ( J:96785 )

• B cells proliferated, on average, 3.8 times faster than controls and showed a 3.5-fold increase in the number of cells in S phase of the cell cycle in 4- to 6-month old, tumor-free mutants

• B splenocytes proliferated more vigorously than controls after stimulation with LPS

growth/size/body

enlarged spleen ( J:96785 )

• spleen was enlarged in 4- to 6-month old tumor-free mice because of progressive, follicular hyperplasia indicative of B cell accumulation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:96785