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Phenotypes Associated with This Genotype
Genotype
MGI:3576483
Allelic
Composition		 Airetm1Mmat/Airetm1Mmat
Genetic
Background		 B6.Cg-Airetm1Mmat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (1 available); any Aire mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:96580 )
• infiltration of many lymphoid cells in the salivary glands
autoimmune response ( J:96580 )
• exhibited similar autoimmune phenotypes as seen in the mixed C57BL/6 and CBA background

endocrine/exocrine glands
salivary gland inflammation ( J:96580 )
• infiltration of many lymphoid cells in the salivary glands

digestive/alimentary system
salivary gland inflammation ( J:96580 )
• infiltration of many lymphoid cells in the salivary glands

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autoimmune polyendocrine syndrome type 1 DOID:0050167 OMIM:240300
 J:96580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory