Phenotypes Associated with This Genotype

Genotype
MGI:3576735

• Allelic Composition: Sh2d1a^tm1Cpt/Sh2d1a^tm1Cpt
• Genetic Background: C.129S4-Sh2d1a^tm1Cpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased spleen germinal center number ( J:97388 )

♀ • after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles

decreased IgG level ( J:97388 )

♀ • after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses

♀ • IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant

decreased IgM level ( J:97388 )

♀ • after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen

hematopoietic system

decreased spleen germinal center number ( J:97388 )

♀ • after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles

decreased IgG level ( J:97388 )

♀ • after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses

♀ • IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant

decreased IgM level ( J:97388 )

♀ • after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
X-linked lymphoproliferative syndrome 1		DOID:0060705	OMIM:308240	J:97388