Phenotypes Associated with This Genotype

Genotype
MGI:3576767

• Allelic Composition: Tg(Cryaa-TAg,Ins2-CALM1)26Ove/0
• Genetic Background: FVB(Cg)-Tg(Cryaa-Tag,Ins2-CALM1)26Ove/PneJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:97926 )

• reduced pancreatic insulin levels; early onset and increased severity with age

• pancreatic insulin content was 28% of control levels

• insulin mRNA levels were also reduced

hyperglycemia ( J:97926 )

increased circulating glucagon level ( J:97926 )

• elevated serum glucagon levels

decreased circulating insulin level ( J:97926 )

• markedly lower serum insulin levels

increased urine glucose level ( J:97926 )

renal/urinary system

increased urine glucose level ( J:97926 )

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:97926 )

• the number of beta cells per islet was reduced

decreased insulin secretion ( J:97926 )

• reduced pancreatic insulin levels; early onset and increased severity with age

• pancreatic insulin content was 28% of control levels

• insulin mRNA levels were also reduced

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:97926