Phenotypes Associated with This Genotype

Genotype
MGI:3577096

• Allelic Composition: Tg(MMTVneu)202Mul/0
• Genetic Background: FVB/N-Tg(MMTVneu)202Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:56332 )

• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal

• focal adenocarcinomas surrounded by hyperplastic mammary epithelium

increased metastatic potential ( J:56332 )

• 72% of the tumor-bearing mice that lived to an age of 8 months or older developed metastases to the lung

• multiple foci of metastatic mammary adenocarcinoma lodged in pulmonary vessels were observed

integument

increased mammary adenocarcinoma incidence ( J:56332 )

• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal

• focal adenocarcinomas surrounded by hyperplastic mammary epithelium

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:56332 )

• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal

• focal adenocarcinomas surrounded by hyperplastic mammary epithelium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:56332