Phenotypes Associated with This Genotype

Genotype
MGI:3577766

• Allelic Composition: Angptl6^tm1Yo/Angptl6^tm1Yo
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:97552 )

• approximately 80% of homozygous null mice die at about E13

cardiovascular system

abnormal cardiovascular development ( J:97552 )

• homozygotes die at around E13 with cardiovascular defects

abnormal vitelline vasculature morphology ( J:97552 )

• poorly formed vitelline vessels in homozygotes that die at E13

embryo

abnormal vitelline vasculature morphology ( J:97552 )

• poorly formed vitelline vessels in homozygotes that die at E13

abnormal visceral yolk sac morphology ( J:97552 )

• poorly formed sack in homozygotes that die at E13

growth/size/body

obese ( J:97552 )

• surviving (about 20%) homozygotes become markedly obese even on a normal chow diet

adipose tissue

increased total body fat amount ( J:97552 )

• visceral and subcutaneous fat depots were significantly increased at 8 months after birth

abnormal white adipose tissue morphology ( J:97552 )

• white adipose tissue showed increased adipocyte size at 8 months of age

homeostasis/metabolism

hyperglycemia ( J:97552 )

• exhibit mild hyperglycemia

increased circulating insulin level ( J:97552 )

• exhibit severe hyperinsulinemia

increased circulating leptin level ( J:97552 )

• leptin concentration was significantly higher than in controls, however no differences in adiponectin or TNF-alpha concentrations

decreased core body temperature ( J:97552 )

• decrease in rectal temperature

decreased oxygen consumption ( J:97552 )

• decrease in whole-body oxygen consumption rates

insulin resistance ( J:97552 )

abnormal lipid homeostasis ( J:97552 )

• large amount of lipid accumulation in liver, skeletal muscle and brown adipose tissue was seen in 8 month old homozygotes

increased circulating cholesterol level ( J:97552 )

• significant increase in serum cholesterol however no differences in serum triglyceride concentration

increased circulating free fatty acids level ( J:97552 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:97552