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Phenotypes Associated with This Genotype
Genotype
MGI:3578233
cx3
Allelic
Composition		 Ep300tm1Pkb/Ep300+
Mybtm1Ssp/Myb+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300tm1Pkb mutation (2 available); any Ep300 mutation (98 available)
Mybtm1Ssp mutation (1 available); any Myb mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:98329 )
• 40% reduction in numbers
abnormal megakaryocyte morphology ( J:98329 )
• megakaryocyte ploidy reduced relative to controls
thrombocytosis ( J:98329 )
• large increase in platelet numbers seen at 2-3 weeks of age but not at 5-6 weeks

immune system
decreased thymocyte number ( J:98329 )
• 40% reduction in numbers

endocrine/exocrine glands
decreased thymocyte number ( J:98329 )
• 40% reduction in numbers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory