Phenotypes Associated with This Genotype

Genotype
MGI:3578951

• Allelic Composition: Irf8^myls/Irf8^myls; Slc11a1^r/Slc11a1^r
• Genetic Background: BXH2/TyJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:97931 )

• die within 10 months of age

immune system

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

decreased interferon-gamma secretion ( J:97931 )

• splenocytes did not secrete IFN-gamma in response to LPS treatment

decreased interleukin-12 secretion ( J:97931 )

• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma

increased susceptibility to bacterial infection ( J:97931 )

• increased susceptibility to Mycobacterium bovis (BCG) infection

neoplasm

increased chronic myelocytic leukemia incidence ( J:97931 )

• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

abnormal myelopoiesis ( J:97931 )

• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

growth/size/body

enlarged spleen ( J:97931 )

• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:97931