Phenotypes for Irf8 Slc11a1 MGI:3578958 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Irf8^myls/Irf8^myls Slc11a1^r/Slc11a1^r
Genetic Background	involves: A/J * BXH2/TyJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8^myls mutation (1 available); any Irf8 mutation (35 available)
Slc11a1^r mutation (2 available); any Slc11a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:97931 )

• die within 10 months of age

neoplasm

increased chronic myelocytic leukemia incidence ( J:97931 )

• develop fatal leukemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial chronic myelocytic leukemia-like syndrome		DOID:0060761	OMIM:600080	J:97931

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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