Analysis Tools
hematopoietic system
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• definitive erythropoiesis is impaired
• at E14.0, fewer cells beyond the polychromatic erythroblast stage are seen are seen in the liver
• differentiation of erythroid progenitors in the hanging drop assay is intermediate between wild-type mice and males hemizygous for Tg(HBB-Gata1)G4Phi
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• anemia is seen at E13.5 - E14.0; however, the rate of embryonic death is not increased compared to wild-type embryos
• anemia is transient (not present at birth), variable, and not as severe as in hemizygous males; however at E13.5, about 4% of the total circulating blood cells are immature erythroid precursors
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