Phenotypes Associated with This Genotype

Genotype
MGI:3579532

• Allelic Composition: Mdk^tm1Tmu/Mdk^tm1Tmu
• Genetic Background: B6.129S2-Mdk^tm1Tmu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage chemotaxis ( J:102069 )

• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased

impaired neutrophil chemotaxis ( J:102069 )

• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

decreased macrophage cell number ( J:102069 )

behavior/neurological

behavior/neurological phenotype ( J:151029 )

N • mice exhibit normal locomotor activity and acoustic startle reactivity

abnormal social investigation ( J:151029 )

• mice make less frequent contacts, longer times in total contacts, and longer times per one contact compared with wild-type mice

nervous system

decreased prepulse inhibition ( J:151029 )

• adult mice exhibit reduced prepulse inhibition compared with wild-type mice

• however, prepubertal mice and mice treated with haloperidol or clozapine exhibit normal prepulse inhibition

hearing/vestibular/ear

abnormal hearing physiology ( J:110520 )

• mice experience low to moderate levels of auditory deficits

homeostasis/metabolism

abnormal circulating enzyme level ( J:102069 )

• following partial hepatectomy (PH), amino-transferase levels are decreased

decreased dopamine level ( J:151029 )

• in the striatum

abnormal wound healing ( J:88890 )

• less severe adhesions of the intestine after partial hepatectomy (50% as opposed to 100%)

• omental adhesions reduced after peritoneal wall injury

liver/biliary system

decreased hepatocyte number ( J:102069 )

decreased liver weight ( J:102069 )

• one day following partial hepatectomy (PH)

hematopoietic system

abnormal macrophage chemotaxis ( J:102069 )

• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased

impaired neutrophil chemotaxis ( J:102069 )

• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

decreased macrophage cell number ( J:102069 )

cellular

abnormal macrophage chemotaxis ( J:102069 )

• following partial hepatectomy (PH), macrophage infiltration into the liver is decreased

impaired neutrophil chemotaxis ( J:102069 )

• following partial hepatectomy (PH), neutrophil infiltration into the liver is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:151029