Phenotypes Associated with This Genotype

Genotype
MGI:3580003

• Allelic Composition: Tg(Crh)227.1Pbl/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

enlarged adrenal glands ( J:92996 )

• transgenic mice exhibit increased adrenal weights

decreased thymus weight ( J:92996 )

• transgenic mice show a ~2-fold reduction in thymus weight

hypersecretion of adrenocorticotropin ( J:92996 )

• transgenic mice exhibit elevated ACTH release

homeostasis/metabolism

increased circulating corticosterone level ( J:92996 )

• notably, addition of zinc in the drinking water does not further increase the corticosterone levels in founder mice

• transgenic mice show up to a 10-fold increase in corticosterone levels relative to control non-transgenic littermates; the degree of endocrine dysfunction varies widely among founders

increased circulating adrenocorticotropin level ( J:92996 )

• transgenic mice show a 5-fold elevation in serum levels of ACTH

increased circulating corticotropin-releasing hormone level ( J:92996 )

growth/size/body

obese ( J:92996 )

• transgenic mice exhibit truncal obesity with large adipose deposits

abnormal postnatal growth ( J:92996 )

• transgenic mice display decreased linear growth relative to non-transgenic littermates

muscle

muscular atrophy ( J:92996 )

reproductive system

reduced female fertility ( J:92996 )

♀ • transgenic females show decreased fertility probably due to increased corticosterone levels or CRF levels in the brain

hematopoietic system

decreased thymus weight ( J:92996 )

• transgenic mice show a ~2-fold reduction in thymus weight

decreased spleen weight ( J:92996 )

• transgenic mice show a 3-fold reduction in spleen weight

immune system

decreased thymus weight ( J:92996 )

• transgenic mice show a ~2-fold reduction in thymus weight

decreased spleen weight ( J:92996 )

• transgenic mice show a 3-fold reduction in spleen weight

nervous system

hypersecretion of adrenocorticotropin ( J:92996 )

• transgenic mice exhibit elevated ACTH release

integument

alopecia ( J:92996 )

• transgenic mice display bilateral symmetric hair loss

translucent skin ( J:92996 )

• transgenic mice show abnormally transparent skin

thin skin ( J:92996 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:92996
primary hyperaldosteronism		DOID:446	OMIM:605635 OMIM:613677	J:92996