Phenotypes Associated with This Genotype

Genotype
MGI:3580018

hm2

• Allelic Composition: Mapk10^tm1Flv/Mapk10^tm1Flv
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:43658 )

• resistant to seizures induced by low doses (30mg/kg) of kainic acid

• remain sensitive to pentetrazole induced seizures

• higher doses of kainic acid (45mg/kg)induced seizures similar to those seen in controls but survival was much better, 60% of controls killed by this dose

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:43658 )

• resistant to seizures induced by low doses (30mg/kg) of kainic acid

• remain sensitive to pentetrazole induced seizures

• higher doses of kainic acid (45mg/kg)induced seizures similar to those seen in controls but survival was much better, 60% of controls killed by this dose

decreased neuron apoptosis ( J:124252 )

• lower levels of apoptosis (35%) are induced in primary cortical neuron cultures than in wild-type neurons (55%) after 24 hours of treatment with 25 um Abeta25-35 peptide

• similar results are obtained for treated cultured hippocampal neurons or cortical neurons treated with Abeta 1-40

decreased susceptibility to neuronal excitotoxicity ( J:43658 )

• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid

• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos

cardiovascular system

cardiovascular system phenotype ( J:108253 )

N • exhibit no difference in response to pressure overload compared to wild-type

cellular

abnormal cell death ( J:117956 )

• in mutants, corticospinal neurons are resistant to lesion-induced cell death whereas ~40% of wild-type CSN die after CSN deafferentation at 4 months of age

decreased neuron apoptosis ( J:124252 )

• lower levels of apoptosis (35%) are induced in primary cortical neuron cultures than in wild-type neurons (55%) after 24 hours of treatment with 25 um Abeta25-35 peptide

• similar results are obtained for treated cultured hippocampal neurons or cortical neurons treated with Abeta 1-40

decreased susceptibility to neuronal excitotoxicity ( J:43658 )

• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid

• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:43658 )

• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid

• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos