Phenotypes Associated with This Genotype

Genotype
MGI:3580019

hm1

• Allelic Composition: Mapk10^tm1Flv/Mapk10^tm1Flv
• Genetic Background: B6.129S1-Mapk10^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:87428 )

• improved performance over controls after treatment with MPTP in a rotorod test but only at low speeds

nervous system

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )

• increased resistance to MPTP induced Parkinson's disease

abnormal somatic motor system morphology ( J:96192 )

• 3 fold improvement in neuron survival in the facial motor nucleus after axotomy (37% survive)

• improved neuron survival in dorsal root ganglia as well

homeostasis/metabolism

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )

• increased resistance to MPTP induced Parkinson's disease

abnormal dopamine level ( J:87428 )

• reduced dopamine levels but not as much as seen in controls after MPTP treatment

cellular

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )

• increased resistance to MPTP induced Parkinson's disease