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Phenotypes Associated with This Genotype
Genotype
MGI:3580020
cx3
Allelic
Composition		 Mapk10tm1Flv/Mapk10tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv
Genetic
Background		 B6.129S-Mapk9tm1Flv Mapk10tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation (2 available); any Mapk10 mutation (37 available)
Mapk9tm1Flv mutation (2 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• resistance to MPTP-induced Parkinson's disease
abnormal somatic motor system morphology ( J:96192 )
• much improved neuron survival in the facial motor nucleus after axotomy (52% survive)

behavior/neurological
behavior/neurological phenotype ( J:87428 )
N
• MPTP treatment had no effect on rotarod performance at any speed

homeostasis/metabolism
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• resistance to MPTP-induced Parkinson's disease
abnormal dopamine level ( J:87428 )
• somewhat reduced dopamine levels after MTP treatment

cellular
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• resistance to MPTP-induced Parkinson's disease

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory