Phenotypes Associated with This Genotype

Genotype
MGI:3580073

• Allelic Composition: Nf1^tm1Tyj/Nf1⁺; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:58876 )

• cis-double heterozygotes die by 5 months of age and trans-double heterozygotes survive to the average age of 10 months

neoplasm

increased tumor incidence ( J:58876 )

• cis-double heterozygotes exhibit greater incidence of tumors than trans-double heterozygotes

increased sarcoma incidence ( J:58876 )

• developed in both cis- and trans-double heterozygotes

• sarcomas in trans-double heterozygotes were similar to those found in mice with either single mutation and were usually correlated with loss of one chromosome

increased neurofibrosarcoma incidence ( J:58876 )

• develop in cis-double heterozygotes, usually correlated with loss of one chromosome

nervous system

increased neurofibrosarcoma incidence ( J:58876 )

• develop in cis-double heterozygotes, usually correlated with loss of one chromosome

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neurofibromatosis 1		DOID:0111253	OMIM:162200	J:58876