Phenotypes Associated with This Genotype

Genotype
MGI:3580089

• Allelic Composition: Arhgap6/Hccs/Mid1^tm1Hzo/Arhgap6/Hccs/Mid1^tm1Hzo; Tg(EIIa-cre)C5379Lmgd/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:80528 )

♀ • no homozygous mice born

♀ • 15 of 21 embryos abnormal at E9.5 and E10.5

♀ • mosaic animals were present and were healthy and fertile

embryo

abnormal embryo development ( J:80528 )

♀ • many embryos undergoing resorption by E9.5-E10.5

abnormal gastrulation ( J:80528 )

♀ • gastrulation defects

embryonic growth retardation ( J:80528 )

♀

growth/size/body

embryonic growth retardation ( J:80528 )

♀

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microphthalmia		DOID:10629		J:80528