Phenotypes Associated with This Genotype

Genotype
MGI:3580291

• Allelic Composition: Lmbr1^tm1Kng/Lmbr1^tm1Kng
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:72166 )

• minor coalitions of the distal wrist bones (central to distal carpal 3) are seen in 39% of homozygotes; coalitions are also seen in wild-type mice (32%) but involve central and distal carpal 2

brachyphalangia ( J:72166 )

• seen in 3% of homozygotes

oligodactyly ( J:72166 )

• low incidence (2%) of digit loss through either loss of the 5th digit or fusion of digits 3 and 4

syndactyly ( J:72166 )

• seen in 2% of forelimbs and 1% of hindlimbs

skeleton

abnormal carpal bone morphology ( J:72166 )

• minor coalitions of the distal wrist bones (central to distal carpal 3) are seen in 39% of homozygotes; coalitions are also seen in wild-type mice (32%) but involve central and distal carpal 2

brachyphalangia ( J:72166 )

• seen in 3% of homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acheiropody		DOID:0050603	OMIM:200500	J:72166