Phenotypes Associated with This Genotype

Genotype
MGI:3580533

• Allelic Composition: Prkar1a^tm1.1Lsk/Prkar1a⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:98799 )

• commonly found on proximal hind limb but elsewhere as well

• interlacing bundles of parallel spindle cells with large eosinophilic cytoplasmic granules

• look like hypertrophic Schwann cells - Schwannomas

• no melanotic pigmentation

• tail tumors as well starting around 5 to 6 months

• bone loss in individual vertebrae of the tail

increased thyroid tumor incidence ( J:98799 )

• epithelial thyroid cancer

endocrine/exocrine glands

increased thyroid tumor incidence ( J:98799 )

• epithelial thyroid cancer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Carney complex		DOID:0050471	OMIM:160980 OMIM:605244 OMIM:608837	J:98799