Phenotypes Associated with This Genotype

Genotype
MGI:3580873

ht2

• Allelic Composition: Sod2^tm1.1Kskk/Sod2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:98289 )

• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age

• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age

cellular

increased cardiomyocyte apoptosis ( J:98289 )

• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells

oxidative stress ( J:98289 )

• increased formation of nitrotyrosine is seen in the myocardium of 3 and 10 day old heterozygotes

• clusters of cardiomyocytes show signs of lipid peroxidation in 7 out of 10 heterozygotes at 10 days of age

muscle

abnormal myocardial fiber morphology ( J:98289 )

• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age

• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age

increased cardiomyocyte apoptosis ( J:98289 )

• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells