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Phenotypes Associated with This Genotype
Genotype
MGI:3581437
Allelic
Composition		 Itgb6tm1Des/Itgb6tm1Des
Genetic
Background		 involves: 129T2/SvEms
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
overexpanded pulmonary alveolus ( J:89578 )
• normal alveolar size at 2 months of age, however spontaneously developed progressive alveolar enlargement over time
emphysema ( J:89578 )
• developed pulmonary emphysema over time

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pulmonary emphysema DOID:9675 OMIM:130700
 J:89578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory