Phenotypes Associated with This Genotype

Genotype
MGI:3581438

• Allelic Composition: Itgb6^tm1Des/Itgb6^tm1Des; Mmp12^tm1Sds/Mmp12^tm1Sds
• Genetic Background: involves: 129/Sv * 129T2/SvEms

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

lung inflammation ( J:89578 )

• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

respiratory system

respiratory system phenotype ( J:89578 )

N • did not exhibit alveolar enlargement and did not develop emphysema

lung inflammation ( J:89578 )

• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

integument

alopecia ( J:89578 )

• developed patchy juvenile baldness associated with skin inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	pulmonary emphysema	DOID:9675	OMIM:130700	J:89578