Phenotypes Associated with This Genotype

Genotype
MGI:3581611

• Allelic Composition: Tg(Ins2-Fasl)24Ach/0
• Genetic Background: NOD-Tg(Ins2-Fasl)24Ach/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:78679 , J:81416 )

• majority of mice develop diabetes by 10 weeks of age vs controls which develop diabetes by 12 weeks of age; diabetes determined as blood glucose greater than 250 mg/dl (J:78679)

• mice develop diabetes in ~ 5 days of transfer of diabetogenic T cells (J:81416)

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:78679 )

• at 25 weeks of age, transgenic mice show significant islet damage with little remaining insulin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:78679