Phenotypes Associated with This Genotype

Genotype
MGI:3581822

• Allelic Composition: Tg(GFAP)10Mes/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:146191 )

• mice display <10% mortality at about 30 days of age

postnatal lethality ( J:99256 )

• severely affected mice die around 14 days of age; less affected mice live for more than 1 year

growth/size/body

decreased body size ( J:146191 )

• mice show significantly decreased body weights at 6 weeks and three months relative to wild-type

nervous system

abnormal astrocyte morphology ( J:99256 )

• astrocytes are enlarged and contain large eosinophilic aggregations resembling Rosenthal fibers;

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alexander disease		DOID:4252	OMIM:203450	J:99256