Analysis Tools
mortality/aging
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• most died within 3-4 days of birth, and more than 85% failed to reach weaning age due to increased susceptibility to bacterial infection, however treatment of mothers with antibiotics to inhibit bacterial infection resulted in normal lifespan
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growth/size/body
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• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had highly atrophic nasal turbinates, characterized by a flat and unconvoluted structure
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• nasal passages of homozygous null mice rederived in a Pasteurella pneumontropica-free environment contained pools of eosinophillic fluid suggestive of a proteinaceous exudates
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• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had a diffusely atrophic olfactory epithelium
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broad snout
(
J:64193
)
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• shortened and broadened snout with a characteristic bull-like appearance in adults
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short snout
(
J:64193
)
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• shortened and broadened snout with a characteristic bull-like appearance in adults
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• detected at E13.5, persisted throughout embryonic development and into adulthood in the small percentage of surviving mice
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• birth weight was 20-30% lower than in wild-type and surviving adults consistently weighed 50-65% of controls
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homeostasis/metabolism
dehydration
(
J:64193
)
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• neonates were dehydrated
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behavior/neurological
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• showed degeneration of the intestinal tract that was consistent with starvation
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• surviving mice emitted a chirping sound
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digestive/alimentary system
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• showed degeneration of the intestinal tract that was consistent with starvation
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hematopoietic system
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• increased number of reticulocytes and the presence of nucleated red blood cells indicate stress erythropoiesis in embryos and neonates but was not observed in adults
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• 2-3 fold increase in the number of fetal liver erythroid progenitors
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• 20-30% decrease in number of red blood cells in the peripheral blood of adults
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• 30-40% decrease in hematocrit in embryos, however normal in surviving adults
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• presence of nucleated red blood cells in the peripheral blood in embryos
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anisocytosis
(
J:64193
)
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• erythrocytes varied in size at E16.5-E18.5
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• embryos, neonates, and adults showed a high frequency of erythrocytes containing Howell-Jolly bodies, nuclear remnants leftover from improper enucleation
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macrocytosis
(
J:64193
)
|
• increase in mean erythrocyte volume at E16.5-E18.5
• seen in adults due to general increase in the red blood cell size and not presence of aberrant red blood cell population
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• increased number of reticulocytes in embryos and neonates but not in adults
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immune system
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• middle ear of neonates and surviving adults was completely obstructed by a purulent exudates
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• nasal passages of neonates and surviving adults were completely obstructed by purulent exudates and contained high levels of macrophages and neutrophils
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• high levels of Pasteurella pneumotropica in nasal passages and middle ear most likely due to craniofacial bone abnormalities that prevent the drainage of proteinaceous exudates and clearing of infectious agent
• homozygous null mice were almost fully viable when rederived in a Pasteurella pneumontropica-free environment or when mothers were treated with antibiotics
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respiratory system
|
• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had highly atrophic nasal turbinates, characterized by a flat and unconvoluted structure
|
|
• nasal passages of homozygous null mice rederived in a Pasteurella pneumontropica-free environment contained pools of eosinophillic fluid suggestive of a proteinaceous exudates
|
|
• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had a diffusely atrophic olfactory epithelium
|
|
• nasal passages of neonates and surviving adults were completely obstructed by purulent exudates and contained high levels of macrophages and neutrophils
|
hearing/vestibular/ear
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• middle ear cavities of homozygous null mice rederived in a Pasteurella pneumontropica-free environment contained pools of eosinophillic fluid suggestive of a proteinaceous exudates
|
|
• middle ear of neonates and surviving adults was completely obstructed by a purulent exudates
|
taste/olfaction
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• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had a diffusely atrophic olfactory epithelium
|
craniofacial
|
• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had highly atrophic nasal turbinates, characterized by a flat and unconvoluted structure
|
|
• nasal passages of homozygous null mice rederived in a Pasteurella pneumontropica-free environment contained pools of eosinophillic fluid suggestive of a proteinaceous exudates
|
|
• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had a diffusely atrophic olfactory epithelium
|
broad snout
(
J:64193
)
|
• shortened and broadened snout with a characteristic bull-like appearance in adults
|
short snout
(
J:64193
)
|
• shortened and broadened snout with a characteristic bull-like appearance in adults
|
reproductive system
 |
• analysis of adult mice in which mothers were treated with antibiotics to prevent bacterial infection and thus increase viability, indicated that 90% of females were sterile
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 |
• analysis of adult mice in which mothers were treated with antibiotics to prevent bacterial infection and thus increase viability, indicated that 80% of males were sterile
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embryo
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• detected at E13.5, persisted throughout embryonic development and into adulthood in the small percentage of surviving mice
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skeleton
|
• homozygous null mice rederived in a Pasteurella pneumontropica-free environment had highly atrophic nasal turbinates, characterized by a flat and unconvoluted structure
|
integument
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| otitis media | DOID:10754 | J:64193 | ||
