Phenotypes Associated with This Genotype

Genotype
MGI:3582517

cx3

• Allelic Composition: E2f4^tm1Lees/E2f4^tm1Lees; Rb1^tm1Tyj/Rb1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:81082 )

• two mutant mice died at early stages (2.7 and 5.4 months) as a result of increased susceptibility to infection, however majority of mutant mice survived at least until the window of lethality of the single heterozygous mutant Rb1 mice and a significant fraction lived to an age comparable to wild-type

neoplasm

decreased tumor incidence ( J:81082 )

• suppressed tumor formation compared to single heterozygous mutant Rb1 mice, with no mutants developing pituitary tumors prior to 16 months of age and significantly lower incidence of pituitary tumors thereafter and only 1/17 mutants developing a c-cell thyroid tumor

immune system

increased susceptibility to infection ( J:81082 )

• two mutant mice died at early stages (2.7 and 5.4 months) as a result of increased susceptibility to infection, however showed no evidence of tumorigenic lesions in these mice