Phenotypes Associated with This Genotype

Genotype
MGI:3582673

• Allelic Composition: Blm^tm1Grdn/Blm⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of induced tumors ( J:79058 )

• enhanced T cell tumorigenesis in response to viral challenge with murine leukemia virus, with heterozygous mutant mice exhibiting a shorter life-span than wild-type mice (117 days vs. 184 days in wild-type)

cellular

chromosome breakage ( J:79058 )

• two-fold increase in the number of micronuclei in lung fibroblasts, indicating an increase in genomic instability

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bloom syndrome		DOID:2717	OMIM:210900	J:79058